Intravenous zanamivir or oral oseltamivir for hospitalised patients with influenza: an international, randomised, double-blind, double-dummy, phase 3 trial.
Identifieur interne : 000933 ( Main/Exploration ); précédent : 000932; suivant : 000934Intravenous zanamivir or oral oseltamivir for hospitalised patients with influenza: an international, randomised, double-blind, double-dummy, phase 3 trial.
Auteurs : Francisco M. Marty [États-Unis] ; Joan Vidal-Puigserver [Espagne] ; Carol Clark [États-Unis] ; Sandeep K. Gupta [Inde] ; Esperanza Merino [Espagne] ; Denis Garot [France] ; Marianne J. Chapman [Australie] ; Frédérique Jacobs [Belgique] ; Eduardo Rodriguez-Noriega [Mexique] ; Petr Husa [République tchèque] ; Denise Shortino [États-Unis] ; Helen A. Watson [Royaume-Uni] ; Phillip J. Yates [Royaume-Uni] ; Amanda F. Peppercorn [États-Unis]Source :
- The Lancet. Respiratory medicine [ 2213-2619 ] ; 2017.
Abstract
Neuraminidase inhibitors are effective for the treatment of acute uncomplicated influenza. However, there is an unmet need for intravenous treatment for patients admitted to hospital with severe influenza. We studied whether intravenous zanamivir was a suitable treatment in this setting.
DOI: 10.1016/S2213-2600(16)30435-0
PubMed: 28094141
Affiliations:
- Australie, Belgique, Espagne, France, Inde, Mexique, Royaume-Uni, République tchèque, États-Unis
- Caroline du Nord, Centre-Val de Loire, Massachusetts, Michigan, Région Centre, Région de Bruxelles-Capitale
- Bruxelles, Tours
- Université libre de Bruxelles
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Marty</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: fmarty@bwh.harvard.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Vidal Puigserver, Joan" sort="Vidal Puigserver, Joan" uniqKey="Vidal Puigserver J" first="Joan" last="Vidal-Puigserver">Joan Vidal-Puigserver</name><affiliation wicri:level="1"><nlm:affiliation>Servei d'Urgències, Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Servei d'Urgències, Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears</wicri:regionArea><wicri:noRegion>Illes Balears</wicri:noRegion></affiliation></author><author><name sortKey="Clark, Carol" sort="Clark, Carol" uniqKey="Clark C" first="Carol" last="Clark">Carol Clark</name><affiliation wicri:level="2"><nlm:affiliation>Department of Emergency Medicine, William Beaumont Hospital, Royal Oak, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Emergency Medicine, William Beaumont Hospital, Royal Oak, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Gupta, Sandeep K" sort="Gupta, Sandeep K" uniqKey="Gupta S" first="Sandeep K" last="Gupta">Sandeep K. Gupta</name><affiliation wicri:level="1"><nlm:affiliation>M V Hospital & Research Centre, Lucknow, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>M V Hospital & Research Centre, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation></author><author><name sortKey="Merino, Esperanza" sort="Merino, Esperanza" uniqKey="Merino E" first="Esperanza" last="Merino">Esperanza Merino</name><affiliation wicri:level="1"><nlm:affiliation>Hospital General Universitario de Alicante, Alicante, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital General Universitario de Alicante, Alicante</wicri:regionArea><wicri:noRegion>Alicante</wicri:noRegion></affiliation></author><author><name sortKey="Garot, Denis" sort="Garot, Denis" uniqKey="Garot D" first="Denis" last="Garot">Denis Garot</name><affiliation wicri:level="3"><nlm:affiliation>Service de Réanimation Polyvalente, Hôpital Bretonneau, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Polyvalente, Hôpital Bretonneau, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Chapman, Marianne J" sort="Chapman, Marianne J" uniqKey="Chapman M" first="Marianne J" last="Chapman">Marianne J. Chapman</name><affiliation wicri:level="1"><nlm:affiliation>Royal Adelaide Hospital, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Adelaide Hospital, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Jacobs, Frederique" sort="Jacobs, Frederique" uniqKey="Jacobs F" first="Frédérique" last="Jacobs">Frédérique Jacobs</name><affiliation wicri:level="4"><nlm:affiliation>Infectious Diseases Department, CUB-Erasme, Université Libre de Bruxelles, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Infectious Diseases Department, CUB-Erasme, Université Libre de Bruxelles, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region><settlement type="city">Bruxelles</settlement></placeName><orgName type="university">Université libre de Bruxelles</orgName></affiliation></author><author><name sortKey="Rodriguez Noriega, Eduardo" sort="Rodriguez Noriega, Eduardo" uniqKey="Rodriguez Noriega E" first="Eduardo" last="Rodriguez-Noriega">Eduardo Rodriguez-Noriega</name><affiliation wicri:level="1"><nlm:affiliation>Infectología, Hospital Civil de Guadalajara Fray Antonio Alcalde; Instituto de Patología Infecciosa y Experimental, CUCS, UDG Guadalajara, Jalisco, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Infectología, Hospital Civil de Guadalajara Fray Antonio Alcalde; Instituto de Patología Infecciosa y Experimental, CUCS, UDG Guadalajara, Jalisco</wicri:regionArea><wicri:noRegion>Jalisco</wicri:noRegion></affiliation></author><author><name sortKey="Husa, Petr" sort="Husa, Petr" uniqKey="Husa P" first="Petr" last="Husa">Petr Husa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Infectious Diseases, Faculty of Medicine, Masaryk University; University Hospital Brno, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Infectious Diseases, Faculty of Medicine, Masaryk University; University Hospital Brno</wicri:regionArea><wicri:noRegion>Masaryk University; University Hospital Brno</wicri:noRegion></affiliation></author><author><name sortKey="Shortino, Denise" sort="Shortino, Denise" uniqKey="Shortino D" first="Denise" last="Shortino">Denise Shortino</name><affiliation wicri:level="2"><nlm:affiliation>PAREXEL International, Research Triangle Park, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>PAREXEL International, Research Triangle Park, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Watson, Helen A" sort="Watson, Helen A" uniqKey="Watson H" first="Helen A" last="Watson">Helen A. Watson</name><affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline, Stockley Park, Middlesex, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>GlaxoSmithKline, Stockley Park, Middlesex</wicri:regionArea><wicri:noRegion>Middlesex</wicri:noRegion></affiliation></author><author><name sortKey="Yates, Phillip J" sort="Yates, Phillip J" uniqKey="Yates P" first="Phillip J" last="Yates">Phillip J. Yates</name><affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline, Stevenage, Herts, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>GlaxoSmithKline, Stevenage, Herts</wicri:regionArea><wicri:noRegion>Herts</wicri:noRegion></affiliation></author><author><name sortKey="Peppercorn, Amanda F" sort="Peppercorn, Amanda F" uniqKey="Peppercorn A" first="Amanda F" last="Peppercorn">Amanda F. Peppercorn</name><affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GlaxoSmithKline, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Respiratory medicine</title><idno type="eISSN">2213-2619</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neuraminidase inhibitors are effective for the treatment of acute uncomplicated influenza. However, there is an unmet need for intravenous treatment for patients admitted to hospital with severe influenza. We studied whether intravenous zanamivir was a suitable treatment in this setting.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Espagne</li><li>France</li><li>Inde</li><li>Mexique</li><li>Royaume-Uni</li><li>République tchèque</li><li>États-Unis</li></country><region><li>Caroline du Nord</li><li>Centre-Val de Loire</li><li>Massachusetts</li><li>Michigan</li><li>Région Centre</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li><li>Tours</li></settlement><orgName><li>Université libre de Bruxelles</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Marty, Francisco M" sort="Marty, Francisco M" uniqKey="Marty F" first="Francisco M" last="Marty">Francisco M. Marty</name></region><name sortKey="Clark, Carol" sort="Clark, Carol" uniqKey="Clark C" first="Carol" last="Clark">Carol Clark</name><name sortKey="Peppercorn, Amanda F" sort="Peppercorn, Amanda F" uniqKey="Peppercorn A" first="Amanda F" last="Peppercorn">Amanda F. Peppercorn</name><name sortKey="Shortino, Denise" sort="Shortino, Denise" uniqKey="Shortino D" first="Denise" last="Shortino">Denise Shortino</name></country><country name="Espagne"><noRegion><name sortKey="Vidal Puigserver, Joan" sort="Vidal Puigserver, Joan" uniqKey="Vidal Puigserver J" first="Joan" last="Vidal-Puigserver">Joan Vidal-Puigserver</name></noRegion><name sortKey="Merino, Esperanza" sort="Merino, Esperanza" uniqKey="Merino E" first="Esperanza" last="Merino">Esperanza Merino</name></country><country name="Inde"><noRegion><name sortKey="Gupta, Sandeep K" sort="Gupta, Sandeep K" uniqKey="Gupta S" first="Sandeep K" last="Gupta">Sandeep K. Gupta</name></noRegion></country><country name="France"><region name="Centre-Val de Loire"><name sortKey="Garot, Denis" sort="Garot, Denis" uniqKey="Garot D" first="Denis" last="Garot">Denis Garot</name></region></country><country name="Australie"><noRegion><name sortKey="Chapman, Marianne J" sort="Chapman, Marianne J" uniqKey="Chapman M" first="Marianne J" last="Chapman">Marianne J. 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